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This document outlines the essential safety information and warnings associated with the use of Itraconazole (Sporanox) oral solution. It is crucial to thoroughly review these warnings and discuss any concerns with your healthcare provider to ensure safe use of this medication.

• Heart Failure Risk: Itraconazole (Sporanox) oral solution may lead to heart failure, particularly in individuals with pre-existing heart conditions, chronic obstructive pulmonary disease (COPD), kidney issues, or conditions causing body swelling. Inform your healthcare provider of all your medical conditions before initiating treatment. Seek immediate medical attention if you experience symptoms such as difficulty breathing, unusual fatigue, swelling of the limbs, sudden weight gain, or a rapid heartbeat.

• Abnormal Heart Rhythm: This medication can cause severe heart rhythm issues when taken with certain drugs like cisapride, pimozide, methadone, or quinidine. Should you experience symptoms such as a pounding heart, difficulty breathing, chest pain, or feeling faint, contact emergency services immediately.

• Drug Interactions: Itraconazole (Sporanox) oral solution can interact with various medications, including specific vitamins and herbal products. Some interactions may be severe or life-threatening, so it is critical to inform your healthcare provider about all medications and supplements you are taking.

• Liver Damage: There is a rare risk of serious liver damage, potentially occurring within the first week of treatment. Your healthcare provider may monitor your liver function during treatment. Discontinue use and contact your provider if you notice symptoms like yellowing of the skin or eyes, dark urine, pale stools, or unusual fatigue.

• Hearing Loss: This medication may cause hearing loss, which can sometimes be permanent. If you experience hearing difficulties, contact your healthcare provider immediately. Note that the risk is higher if you are taking quinidine or are an older adult.

• Nerve Damage: Stop taking Itraconazole (Sporanox) oral solution and consult your healthcare provider if you experience tingling sensations, loss of sensation, tremors, or other signs of nerve damage.

Contraindications: Do not use Itraconazole (Sporanox) oral solution if you:

• Have heart failure.
• Are taking medications known to interact with it, especially those that prolong QT interval (e.g., dofetilide, quinidine, pimozide, methadone, disopyramide, dronedarone, ranolazine).
• Are on dihydroergotamine or ergotamine.
• Have kidney or liver issues and are taking colchicine, fesoterodine, or solifenacin.

Consult your healthcare provider if any of these conditions apply to you prior to starting treatment with Itraconazole (Sporanox) oral solution.

When using this medication, it's important to be aware of possible side effects. Commonly reported side effects include nausea and diarrhea, both affecting about 11% of users, as well as vomiting and fever, each occurring in 7% of cases. Stomach pain is experienced by 6% of individuals. These side effects are generally mild, but if they persist or become bothersome, consulting a healthcare professional is advisable.

Other side effects have been noted, which can vary in their impact. These include rash, constipation, tiredness, coughing, dizziness, sweating, headache, trouble breathing, and chest pain. If you experience any of these, particularly if they are severe, it is recommended to seek medical advice.

There are also rare but serious side effects that warrant immediate medical attention. These include congestive heart failure, indicated by symptoms such as trouble breathing, swelling of the arms and legs, sudden weight gain, and fatigue. Abnormal heart rhythms may cause dizziness or lightheadedness. Liver damage can present with nausea, vomiting, unusual tiredness, jaundice, dark urine, and pale stools. Additionally, hearing loss, characterized by muffled hearing or difficulty understanding speech, requires urgent care. Always remain vigilant for these serious symptoms and seek prompt medical assistance if they arise.