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This document outlines the essential safety information and warnings associated with the use of Itraconazole (Sporanox) oral solution. It is crucial to thoroughly review these warnings and discuss any concerns with your healthcare provider to ensure safe use of this medication.

• Heart Failure Risk: Itraconazole (Sporanox) oral solution may lead to heart failure, particularly in individuals with pre-existing heart conditions, chronic obstructive pulmonary disease (COPD), kidney issues, or conditions causing body swelling. Inform your healthcare provider of all your medical conditions before initiating treatment. Seek immediate medical attention if you experience symptoms such as difficulty breathing, unusual fatigue, swelling of the limbs, sudden weight gain, or a rapid heartbeat.

• Abnormal Heart Rhythm: This medication can cause severe heart rhythm issues when taken with certain drugs like cisapride, pimozide, methadone, or quinidine. Should you experience symptoms such as a pounding heart, difficulty breathing, chest pain, or feeling faint, contact emergency services immediately.

• Drug Interactions: Itraconazole (Sporanox) oral solution can interact with various medications, including specific vitamins and herbal products. Some interactions may be severe or life-threatening, so it is critical to inform your healthcare provider about all medications and supplements you are taking.

• Liver Damage: There is a rare risk of serious liver damage, potentially occurring within the first week of treatment. Your healthcare provider may monitor your liver function during treatment. Discontinue use and contact your provider if you notice symptoms like yellowing of the skin or eyes, dark urine, pale stools, or unusual fatigue.

• Hearing Loss: This medication may cause hearing loss, which can sometimes be permanent. If you experience hearing difficulties, contact your healthcare provider immediately. Note that the risk is higher if you are taking quinidine or are an older adult.

• Nerve Damage: Stop taking Itraconazole (Sporanox) oral solution and consult your healthcare provider if you experience tingling sensations, loss of sensation, tremors, or other signs of nerve damage.

Contraindications: Do not use Itraconazole (Sporanox) oral solution if you:

• Have heart failure.
• Are taking medications known to interact with it, especially those that prolong QT interval (e.g., dofetilide, quinidine, pimozide, methadone, disopyramide, dronedarone, ranolazine).
• Are on dihydroergotamine or ergotamine.
• Have kidney or liver issues and are taking colchicine, fesoterodine, or solifenacin.

Consult your healthcare provider if any of these conditions apply to you prior to starting treatment with Itraconazole (Sporanox) oral solution.

Sporanox (itraconazole) is an antifungal medication that can interact with a wide range of other drugs, potentially leading to serious health risks. It's crucial to inform your healthcare provider about all medications you're currently taking, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements, to avoid harmful interactions.

Medications to Avoid While Taking Sporanox:

• Certain Heart Medications: Combining Sporanox with drugs like quinidine, disopyramide, Dofetilide, and dronedarone can increase the risk of serious heart problems, including life-threatening arrhythmias.

• Ergot Alkaloids: Medications such as ergotamine and Dihydroergotamine, used to treat migraines, should not be taken with Sporanox due to the risk of severe side effects.

• Statins: Cholesterol-lowering drugs like Lovastatin and Simvastatin can interact with Sporanox, increasing the risk of muscle damage.

• Certain Sedatives: Benzodiazepines such as Triazolam and oral midazolam may have enhanced sedative effects when taken with Sporanox, leading to prolonged drowsiness or respiratory issues.

• Methadone: Used for pain relief and as part of drug addiction detox programs, methadone can interact with Sporanox, increasing the risk of serious heart problems.

Other Notable Interactions:

• Calcium Channel Blockers: Medications like felodipine and nisoldipine, used to treat high blood pressure, can have increased effects when taken with Sporanox, potentially leading to low blood pressure or heart issues.

• Anticoagulants: Blood thinners such as Warfarin may have enhanced effects when combined with Sporanox, increasing the risk of bleeding.

• Certain Antidepressants: Drugs like Venlafaxine may have increased levels in the blood when taken with Sporanox, leading to heightened side effects.

Medications That May Reduce Sporanox Effectiveness:

• Antacids and Acid Reducers: Medications that decrease stomach acid, such as proton pump inhibitors (e.g., Omeprazole) and H2 blockers (e.g., ranitidine), can reduce the absorption of Sporanox, making it less effective. It's recommended to take Sporanox with an acidic beverage like cola to improve absorption if you're using these medications.

• Certain Anticonvulsants: Drugs like Phenytoin and Carbamazepine can lower Sporanox levels in the blood, reducing its effectiveness.

Important Considerations:

• Heart Failure: Sporanox should not be used to treat fungal nail infections in individuals with evidence of ventricular dysfunction, such as congestive heart failure (CHF) or a history of CHF.

• Liver Function: Monitor for signs of liver dysfunction while taking Sporanox, and discontinue use if liver issues develop.

• Pregnancy and Breastfeeding: Sporanox should be used during pregnancy only if prescribed, as it may harm a fetus. It passes into breast milk, so consult your doctor before breastfeeding.

Always consult your healthcare provider before starting or stopping any medication while on Sporanox to ensure safety and effectiveness.