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The following safety information outlines essential warnings and risks associated with the use of this medication. It's crucial to review these carefully and discuss any concerns with your healthcare provider.

• Masking of Serious Conditions: Persistent GERD symptoms could indicate a more serious condition like stomach cancer. If symptoms worsen or return after using rabeprazole (Aciphex), or if you experience poor appetite, unexplained weight loss, or weakness, contact your healthcare provider.

• Acute Kidney Issues: There is a rare risk of sudden kidney inflammation while taking PPIs. Seek medical advice if you notice changes in urination, nausea, weakness, fever, rash, or joint pain.

• Severe Infectious Diarrhea: Use of rabeprazole (Aciphex) may increase the risk of infectious diarrhea, especially in those over 65, individuals with a recent hospital or nursing home stay, or those with weakened immune systems. To minimize risk, use the lowest effective dose for the shortest duration. Report severe diarrhea, fever, abdominal pain, loss of appetite, or nausea to your provider immediately.

• Increased Risk of Bone Fractures: Prolonged or high-dose use of rabeprazole (Aciphex) can elevate the risk of fractures in the hip, wrist, or spine. Discuss your fracture risk with your provider, particularly if you have a history of fractures or osteoporosis.

• Serious Skin Reactions: Rare but severe skin reactions like Stevens-Johnson syndrome and toxic epidermal necrolysis have been reported. Symptoms include fever, body aches, rash, peeling skin, blisters, and facial swelling. Seek immediate medical attention if these occur.

• Lupus: Rabeprazole (Aciphex) may trigger or worsen lupus, an autoimmune condition. Symptoms like joint pain or rash may arise during treatment but often improve within 1 to 3 months after discontinuing the medication. Discontinue use and consult your provider if symptoms develop.

• Vitamin B12 and Magnesium Deficiency: Long-term use (3 years or more) of acid-lowering medications can reduce vitamin B12 absorption. Symptoms of deficiency include dizziness, muscle weakness, pale skin, fatigue, or tingling in extremities. Discuss these symptoms with your provider.

• Drug Interactions: Rabeprazole (Aciphex) can interfere with other medications, notably Edurant (rilpivirine). This interaction can reduce the effectiveness of Edurant, potentially leading to HIV spread. Avoid concurrent use of these medications.

Contraindications:

• Do not use rabeprazole (Aciphex) if you are taking Edurant (rilpivirine) or rilpivirine-containing medications, such as Complera, due to the risk of serious health complications. Always consult your healthcare provider if you have any of these conditions.

When taking this medication, some common side effects may occur, which are usually mild and manageable. These include headache, sore throat, passing gas, infections, constipation, belly pain, dry mouth, dizziness, and swelling of the hands and feet. If these effects persist or worsen, consulting a healthcare provider can provide reassurance and guidance.

However, there are rare and more serious side effects that require immediate medical attention. These include signs of kidney problems such as changes in urination, fever, or poor appetite, as well as symptoms of lupus like joint pain and skin rashes that worsen with sunlight. Be aware of any severe stomach pain, diarrhea, or signs of a serious skin reaction, such as blistering or peeling, which demand urgent care.

Additionally, a severe intestinal condition linked to the bacteria C. difficile, which can occur during or after treatment, requires prompt attention if symptoms such as persistent diarrhea, abdominal pain, or blood/mucus in stool develop. Do not use anti-diarrhea or opioid products, as they may worsen these symptoms.

Rarely, this medication may cause vitamin B-12 deficiency, especially if used daily over a long period. Symptoms like unusual weakness, a sore tongue, or numbness/tingling in the hands or feet should be discussed with a healthcare provider. Although a very serious allergic reaction is rare, seek immediate help if you experience fever, swollen lymph nodes, rash, itching, severe dizziness, or trouble breathing.

Rabeprazole, also known by the brand name Aciphex, can interact with various other medications, potentially altering their effectiveness or increasing the risk of side effects. It is crucial to inform your doctor and pharmacist about all other medications or supplements you are taking, whether they are prescription, over-the-counter, vitamins, or herbal products.

Rabeprazole reduces stomach acid, which can affect the absorption and effectiveness of certain drugs. This includes medications such as Ampicillin, Atazanavir, Erlotinib, levoketoconazole, nelfinavir, pazopanib, rilpivirine, and some azole antifungals like Itraconazole, Ketoconazole, and Posaconazole.

Certain medications, such as rilpivirine, are not recommended for use with rabeprazole. If you are prescribed both, your doctor may need to adjust your treatment plan. Other drugs like Methotrexate, especially in high doses, may also require special attention when used with rabeprazole. In some cases, your doctor may adjust the dosage or frequency of these medications.

Furthermore, rabeprazole may interfere with lab tests, leading to inaccurate results. Therefore, it is important to ensure that all healthcare professionals involved in your care are aware that you are taking this medication. Always follow your healthcare provider's instructions and discuss any concerns or questions you may have about your treatment.