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This document outlines essential safety warnings and contraindications for the use of naratriptan, a medication commonly prescribed for migraines. It is crucial to familiarize yourself with these guidelines and consult your healthcare provider for any clarifications or concerns.

• Heart Risks and High Blood Pressure: Naratriptan can cause rare but serious heart-related issues, including heart attacks and irregular heartbeats, shortly after ingestion. It may also elevate blood pressure to dangerous levels. Individuals at higher risk include those with a history of heart conditions, individuals over 65, those with diabetes, obesity, high blood pressure, and smokers.

• Stroke and Brain Injuries: There is a risk of life-threatening strokes or brain bleeding associated with triptans like naratriptan. Patients with a history of stroke are advised against using this medication. Always inform your healthcare provider about your medical history.

• Vascular Narrowing: The drug can cause severe narrowing of blood vessels, potentially leading to serious stomach issues, vision disturbances, and changes in sensation in extremities. Symptoms similar to Raynaud's phenomenon may occur, such as color changes in hands and feet. Discontinue use and consult a healthcare professional if these symptoms arise.

• Medication Overuse Headaches: Excessive use of naratriptan can result in reduced efficacy and more frequent migraines. If you find yourself using migraine medications more than 9 days a month or experiencing more than four migraines a month, consult your healthcare provider for better management options.

• Serotonin Syndrome: There is a rare but serious risk of serotonin syndrome, a condition caused by excess serotonin in the brain, especially if taking other medications that increase serotonin levels.

Contraindications: This medication should not be used if you have any of the following conditions or factors, as it may pose serious health risks:

• Coronary artery disease or coronary artery vasospasm (e.g., Prinzmetal's angina)
• Certain irregular heart rhythms (e.g., Wolff-Parkinson-White syndrome)
• History of stroke or transient ischemic attack
• Uncontrolled high blood pressure
• Peripheral vascular disease or ischemic bowel disease
• Recent use of ergot-containing medications or other triptans within the last 24 hours
• Recent or concurrent use of monoamine oxidase inhibitors (MAOIs) within the last 14 days
• Severe kidney or liver impairments

If any of these conditions apply to you, it is imperative to discuss this with your healthcare provider before starting naratriptan. Always ensure your safety by following professional medical advice and guidelines.

When taking this medication, some common side effects may include flushing, sensations of tingling or numbness, weakness, drowsiness, dizziness, and nausea. These effects are generally mild, but if they persist or worsen, consult your healthcare provider. Additionally, you might experience tiredness, or a "pins and needles" sensation in your limbs, as well as pain or pressure in the throat or neck.

Be aware that this medication could raise your blood pressure, so regular monitoring is advisable. Inform your healthcare provider if you notice any significant increase in blood pressure readings. Although the chest, jaw, or neck tightness and pain associated with this medication are usually not serious, they resemble heart attack symptoms like shortness of breath and unusual sweating. Seek immediate medical attention if these or other serious symptoms occur, including a fast or irregular heartbeat, fainting, severe stomach pain, or bloody diarrhea.

Rare but serious side effects include serotonin syndrome, characterized by a rapid heartbeat, hallucinations, severe dizziness, and muscle twitching. This condition is more likely when combined with other serotonin-boosting drugs. Immediate medical care is necessary if symptoms manifest. Furthermore, rare serious allergic reactions may occur, such as rash, itching, swelling, severe dizziness, or trouble breathing. Seek urgent medical help if these symptoms appear.

Lastly, this medication can cause serious cardiovascular issues, including heart attacks and strokes, denoted by severe headaches, chest pain, or confusion. If you experience any signs of vascular issues, such as partial or permanent vision changes, seek emergency care. Always report any side effects to your healthcare provider to ensure your safety.

When using Naratriptan, it's important to be aware of potential drug interactions. If you're taking ergotamine medications (like Dihydroergotamine) or other "triptan" drugs (such as Zolmitriptan or Rizatriptan), you should space out your doses of naratriptan and these drugs to reduce the risk of serious side effects. Consult your doctor on the appropriate time to wait between doses.

Additionally, the risk of developing serotonin syndrome, a potentially severe condition, increases when Naratriptan is combined with other medications that elevate serotonin levels. This includes certain antidepressants such as SSRIs (e.g., Fluoxetine, paroxetine) and SNRIs (e.g., Duloxetine, Venlafaxine), as well as other drugs like MDMA or herbal supplements such as St. John's wort. The likelihood of serotonin syndrome can be higher when starting or increasing the dosage of these medications.

It's crucial to inform your healthcare provider about all the medications and supplements you are taking, including prescribed, over-the-counter, vitamins, and herbal products. Your doctor might adjust your treatment plan to manage potential interactions effectively.