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You may experience mild side effects such as drowsiness, dizziness, dry mouth, blurred vision, constipation, or trouble sleeping. These are generally not serious, but if they persist or worsen, contact your healthcare provider. To reduce dizziness or lightheadedness, rise slowly from sitting or lying positions.

Some side effects may require prompt medical attention. Notify your healthcare provider if you experience muscle spasms, stiffness, tremors, restlessness, facial expression changes, drooling, swallowing difficulties, or a shuffling walk, as additional medication might be necessary to manage these symptoms.

Serious side effects, though uncommon, include fainting, confusion, depression, suicidal thoughts, difficulty urinating, unusual bruising or bleeding, persistent sore throat, fever, severe abdominal pain, and seizures. In rare instances, thiothixene can cause tardive dyskinesia, characterized by involuntary muscle movements, or increase prolactin levels, leading to symptoms like unwanted breast milk or missed periods in females and decreased sexual ability in males.

Be aware of the potentially life-threatening condition known as neuroleptic malignant syndrome (NMS), with symptoms like fever, severe muscle issues, confusion, sweating, irregular heartbeat, or kidney problems. Seek immediate medical assistance if you experience these signs.

Allergic reactions are rare but serious. If you notice a rash, swelling, severe dizziness, or difficulty breathing, get medical help immediately. Always consult your healthcare provider if you encounter any side effects not listed here.