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Rizatriptan may cause some common side effects, including flushing, tingling or numbness, tiredness, weakness, drowsiness, and dizziness. These are generally mild, but if they persist or worsen, it's important to consult with a healthcare professional. This medication can also elevate blood pressure, so regular monitoring is advisable, and any significant changes should be reported to a healthcare provider.

While many people do not experience serious side effects, there are some to be aware of. Immediate medical attention is needed if you experience symptoms like blue fingers or toes, cold extremities, changes in hearing, or mood alterations. Rizatriptan can also cause chest, jaw, or neck tightness, which is usually not serious, but because these symptoms can mimic a heart attack, it's crucial to seek help if you notice chest pain, shortness of breath, or unusual sweating.

In rare cases, Rizatriptan may lead to serotonin syndrome, a serious condition that can occur if you are taking other medications that increase serotonin. Symptoms include a fast heartbeat, hallucinations, severe dizziness, and nausea. Another rare, but serious, reaction is a severe allergic response, characterized by rash, swelling, or difficulty breathing. Seek immediate medical help if these occur.

Always inform your healthcare provider of all medications you are taking to prevent interactions. If you notice any side effects not mentioned here, contact a medical professional for advice.

Avoid using MAO inhibitors (such as isocarboxazid, Linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, and Tranylcypromine) while taking this medication, as this can lead to a severe and potentially life-threatening interaction. These inhibitors should also be avoided for two weeks before beginning treatment with this medication. Consult your doctor for guidance on when to begin or cease this medication.

Additionally, the likelihood of developing serotonin syndrome or toxicity rises if you are taking drugs that boost serotonin levels. This includes certain street drugs like MDMA/"ecstasy," St. John's wort, and specific antidepressants such as SSRIs (e.g., Fluoxetine, paroxetine) and SNRIs (e.g., Duloxetine, Venlafaxine). The risk is particularly increased when starting or upping the dosage of these medications.

If you are also using ergotamine drugs (like Dihydroergotamine) or "triptan" medications (such as Sumatriptan or Zolmitriptan), make sure to space your rizatriptan dose at least 24 hours apart from these medications to minimize the potential for serious side effects.