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This medication carries several important safety considerations that must be discussed with your healthcare provider before use. Please review the following information carefully to understand the potential risks and necessary precautions associated with this medication:

• Increased Risk in Older Adults with Dementia: There is a slightly elevated risk of severe, potentially life-threatening side effects, such as heart failure, irregular heartbeat, and pneumonia, when this medication is used by older adults with dementia. It is not approved for managing dementia-related behavior issues. Discuss with your doctor the risks and benefits, and explore alternative treatments that may be more suitable.

• Higher Risk of Death in Dementia-Related Psychosis: Individuals aged 65 and older with dementia-related psychosis are at a greater risk of death when taking medications like haloperidol injection. Therefore, it should not be used in this population. Inform your healthcare provider if you or someone you know has dementia before starting this medication.

• Life-Threatening Heart Rhythm Issues (QT Prolongation): This medication can cause QT prolongation, a rare but serious heart rhythm disorder. Your risk increases with certain pre-existing conditions or concurrent medications. Regular heart monitoring via EKG may be necessary. Report any chest pain, breathing difficulties, or lightheadedness to your provider immediately.

• Movement Disorders: Prolonged use or high doses of haloperidol can lead to uncontrolled body movements, which may become permanent, especially in individuals with Parkinson's disease or certain dementias. If such symptoms occur, seek medical advice promptly.

• Neuroleptic Malignant Syndrome (NMS): This rare, life-threatening condition can occur with antipsychotic use, presenting with symptoms like fever, muscle stiffness, and confusion. Immediate medical attention is required if these symptoms develop.

• Risk of Falls: The medication may cause fatigue, low blood pressure, and balance issues, increasing the risk of falls. Stand up slowly from sitting or lying positions and consult your provider if concerned.

• Pneumonia Risk: Older adults, smokers, or those with respiratory issues may have a higher risk of developing lung infections. Seek medical help if experiencing fever, cough, or breathing difficulties.

• Low White Blood Cell Counts: Regular blood tests are advised as the medication can lower white blood cell counts, increasing infection risk. Alert your provider if you notice signs of infection.

• Pregnancy Considerations: Use during pregnancy should weigh the benefits against potential risks to the unborn baby. Discuss with your healthcare provider if you are pregnant or planning to become pregnant.

Contraindications: Do not use this medication if you have conditions that cause slow brain activity, coma, Parkinson's disease, or Lewy body dementia, as these conditions can lead to serious health risks. Always consult with your healthcare provider before starting this medication if you have any of these conditions.

It is crucial to inform your healthcare provider about all medications you are currently taking and any existing health conditions to prevent adverse interactions and ensure safe use of this medication.

When taking this medication, you may experience some common side effects that are generally mild and manageable. These include dizziness, lightheadedness, drowsiness, difficulty urinating, trouble sleeping, headache, and anxiety. Pain at the injection site is also possible. To minimize dizziness and lightheadedness, rise slowly from sitting or lying positions to reduce the risk of falls.

However, there are more significant side effects that require prompt attention. Muscle stiffness or spasms, tremors, restlessness, mask-like facial expressions, drooling, and shuffling walk should be reported to your healthcare provider. These may indicate parkinsonism symptoms or other movement disorders. Occasionally, the medication may lead to a serious condition called tardive dyskinesia, characterized by involuntary facial or muscle movements, such as tongue thrusting and puckering.

Rare but severe side effects necessitate immediate medical care. These include a slow heartbeat, severe dizziness, chest pain, fainting, or symptoms of neuroleptic malignant syndrome (NMS) like fever, muscle pain, confusion, and irregular heartbeat. Additionally, watch for signs of an allergic reaction such as rash, swelling, or difficulty breathing.

In rare instances, the drug may affect hormone levels, leading to unwanted breast milk production, menstrual irregularities, or fertility issues in females, and decreased sexual ability or enlarged breasts in males. A prolonged, painful erection lasting over four hours in males is also a serious concern requiring urgent attention. Always report any unusual or persistent symptoms to your healthcare provider for further guidance.

When using Haloperidol, it's important to be aware of potential interactions with other medications. Inform your doctor or pharmacist about all the medications and supplements you are currently taking, including prescriptions, over-the-counter drugs, vitamins, and herbal products.

Certain drugs should not be used with Haloperidol due to possible serious interactions. These include Bepridil, Bromopride, Cisapride, Dronedarone, Fluconazole, Levomethadyl, Mesoridazine, Metoclopramide, Nelfinavir, Pimozide, Piperaquine, Posaconazole, Saquinavir, Sparfloxacin, Terfenadine, Thioridazine, and Ziprasidone.

There are also medicines that are generally not recommended to be combined with Haloperidol, but may be necessary in specific cases. If prescribed together, your doctor might adjust the dosage or frequency. Some of these drugs are Amiodarone, Amitriptyline, Aripiprazole, Azithromycin, Cabergoline, Cetirizine, Codeine, Erythromycin, Fluoxetine, Ketoconazole, Lithium, Methyldopa, Paroxetine, Pergolide, Quinidine, Sotalol, and many others.

Additionally, using Haloperidol with certain medications may increase the risk of side effects. In some situations, both medications might be necessary, and your doctor will determine the best course of action. Examples include Benztropine, Buspirone, Carbamazepine, Methyldopa, and Rifampin.

Furthermore, Haloperidol can affect heart rhythm (QT prolongation), so it’s crucial to discuss any heart-related medications with your healthcare provider. This includes informing them about any drugs that cause drowsiness, such as opioid pain relievers, alcohol, marijuana, sleep or anxiety medications, muscle relaxants, and antihistamines.

Always check with your pharmacist before using any new products to avoid unwanted interactions.