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Hydromorphone is a medication that carries significant risks, including the potential for abuse, addiction, and overdose, which can be fatal. It may also cause severe breathing difficulties. To minimize these risks, it is crucial to use the lowest effective dose for the shortest duration as advised by your healthcare provider.

• Consider discussing with your doctor or pharmacist about having naloxone on hand to counteract an opioid overdose. Educate your family or those you live with on recognizing the signs of an opioid overdose and how to respond.

• The likelihood of serious breathing issues is heightened when initiating treatment, adjusting the dose, or if the incorrect dose is taken. Combining hydromorphone with alcohol or other substances that induce drowsiness or affect breathing can lead to severe consequences, potentially resulting in death. Ensure you understand how to properly take hydromorphone and which substances to avoid.

• Seek immediate medical attention if you experience very serious side effects such as slow or shallow breathing, unusual lightheadedness, extreme drowsiness or dizziness, or difficulty waking up.

• Store this medication securely to prevent theft, misuse, or abuse. In the event of accidental ingestion, seek emergency medical assistance promptly.

• Women of childbearing age should discuss the potential risks and benefits of this medication with their doctor. If you are pregnant or planning to become pregnant, inform your doctor. During pregnancy, hydromorphone should only be used if absolutely necessary, as it may slightly increase the risk of birth defects in the first trimester. Prolonged use or high doses near delivery may harm the unborn child. To reduce these risks, use the smallest effective dose for the shortest duration. Infants born to mothers who have used this medication long-term may experience severe withdrawal symptoms. Contact your doctor immediately if your newborn exhibits persistent crying, slow or shallow breathing, irritability, tremors, vomiting, diarrhea, poor feeding, or difficulty gaining weight.

• Hydromorphone extended-release is intended for individuals who have been consistently using moderate to high doses of opioid pain medications. It poses a risk of overdose, potentially fatal, if used by someone not accustomed to opioids.

• This extended-release medication is specifically formulated to release hydromorphone slowly. Do not break, crush, dissolve, or chew it, as doing so could result in a fatal overdose.

You might experience nausea, vomiting, constipation, lightheadedness, dizziness, or drowsiness with this medication. These side effects often improve over time. If they persist or worsen, seek advice from your healthcare provider. To help manage constipation, incorporate dietary fiber, stay hydrated, and exercise regularly; a pharmacist can assist with selecting a suitable laxative if needed. To minimize dizziness and lightheadedness, rise slowly from sitting or lying positions. If you notice an empty tablet shell in your stool, it's harmless, as the medicine has been absorbed.

Serious side effects, though less common, require immediate attention. Contact your healthcare provider if you experience sleep apnea, mood changes, severe abdominal pain, difficulty urinating, or signs of adrenal issues like loss of appetite, unusual tiredness, or weight loss. Seek emergency help if you experience fainting, slow or shallow breathing, severe drowsiness, difficulty waking, or seizures. Although rare, serious allergic reactions may occur, characterized by rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing—these demand urgent medical care.

This summary does not cover all possible side effects. If you notice other symptoms, consult your healthcare provider for further guidance.