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The safety and warning information provided below offers crucial details about the potential risks and precautions associated with using this medication. Please read carefully and consult your healthcare provider if you have any questions or concerns.

• Ectopic Pregnancy: The use of progestin-only birth control like Opill (norgestrel) has been linked to cases of ectopic pregnancy, which occurs outside the womb. Seek immediate medical attention if you experience severe lower abdominal pain, as your OB-GYN may need to examine you for an ectopic pregnancy and provide necessary monitoring.

• Ovarian Cysts: Opill (norgestrel) can sometimes lead to the development of ovarian cysts, which typically resolve on their own but may occasionally cause mild abdominal pain or require surgical intervention. Contact your primary care provider if you experience severe abdominal discomfort.

• Irregular Vaginal Bleeding: Changes in menstrual cycles, including breakthrough bleeding and spotting, are common with Opill (norgestrel), affecting approximately 50% of users in clinical studies. In rare instances, these changes could signal a serious condition. Consult your healthcare professional if concerned about irregular bleeding or if you miss a period after recent sexual activity; a pregnancy test may be advisable.

• Liver Damage: Although uncommon, high doses of progestins like Opill (norgestrel) can lead to liver damage. Symptoms include abdominal pain, jaundice, dark urine, and fatigue. Contact your healthcare provider if you exhibit these signs to evaluate your liver health.

• Migraines: Onset or worsening of migraines, or persistent headaches, can occur with Opill (norgestrel) use and may increase stroke risk. Discuss these symptoms with your healthcare provider to determine their cause.

• Drug Interactions: Certain medications, such as seizure drugs (e.g., phenytoin, carbamazepine) and TB medication rifampin, can reduce Opill (norgestrel)'s effectiveness in preventing pregnancy. Other substances, including some antibiotics, HIV medications, and herbal supplements like St. John's wort, may also interfere. Avoid using Opill (norgestrel) within 5 days of taking the emergency contraceptive Ella (ulipristal). Always inform your healthcare provider or pharmacist about all medications and supplements you are taking.

• Allergic Reactions: Opill (norgestrel) contains FD&C Yellow No. 5 (tartrazine), which may trigger allergic reactions, such as hives or breathing issues, in sensitive individuals. If you have an allergy to this dye, consult your healthcare provider before using this medication.

Contraindications: Do not use this medication if any of the following apply, as it may pose serious health risks:

• Currently pregnant.
• Using other hormonal birth control or an intrauterine device (IUD).
• Allergic to FD&C Yellow No. 5 dye.
• Male.
• History of breast cancer or other progestin-sensitive cancers.
• Presence of liver tumors, whether benign or cancerous.
• Unexplained bleeding between periods not diagnosed by a healthcare provider.
• Acute liver disease.

Always consult your healthcare provider to ensure the safe and appropriate use of this medication.

When using this medication, you may experience some mild side effects that are generally manageable. These include nausea, vomiting, dizziness, increased appetite, headache, stomach cramps, bloating, and changes in menstrual periods such as spotting or irregular cycles. It's also common to feel tired, have a backache, or notice some breast discomfort, acne, nervousness, or vaginal discharge. These effects often subside over time, but if they persist or become bothersome, it’s advisable to consult your healthcare provider.

In some cases, more serious side effects can occur, although they are less common. These include mental or mood changes like depression, lumps in the breast, or unusual changes in vaginal bleeding. If you experience severe pain in the abdomen or groin, loss of appetite, yellowing of the eyes or skin, or dark urine, seek medical attention immediately as these could indicate more serious conditions like liver problems or an ectopic pregnancy.

A very serious allergic reaction to this medication is rare, but it's crucial to get immediate medical help if you notice symptoms such as rash, severe dizziness, trouble breathing, or swelling of the face, tongue, or throat. Always be vigilant and report any side effects to your healthcare provider to ensure your safety.