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When considering hormone replacement therapies (HRT), specifically those containing estrogen or a combination of estrogen and progestin, it is crucial to be aware of the potential risks and necessary precautions. Below is a summary of important safety information:

• Blood Clots: Estrogen-containing medications, such as Angeliq (drospirenone/estradiol), can increase the risk of developing serious blood clots, which may be life-threatening. This risk is higher in individuals aged 50 and older, those with high blood pressure, obesity, high cholesterol, diabetes, or a history of smoking or recent surgery. Seek immediate medical attention if you exhibit symptoms of a blood clot.

• Cancer Risks:

  • Breast Cancer: The use of estrogen/progestin HRTs can elevate the risk of breast cancer, particularly with long-term use. Regular breast examinations and mammograms are recommended, and any unusual changes should be reported to your healthcare provider. Avoid use if you currently have or have had breast cancer.
  • Uterine/Endometrial Cancer: Estradiol in HRT can affect the uterine lining, increasing the risk of cancer, especially without the balancing effect of progestin. This risk persists even after discontinuing therapy.
  • Ovarian Cancer: Estrogens may elevate the risk of ovarian cancer.

• Dementia: Women aged 65 and older may face an increased risk of dementia when using estrogen/progestin or estrogen-only therapies. These treatments should not be used to prevent dementia.

• High Potassium Levels: Angeliq can raise blood potassium levels, posing serious health risks, especially for those with kidney, liver issues, or Addison's disease. Regular monitoring of potassium levels is necessary.

• Liver and Gallbladder Issues: Estrogen therapy may heighten the risk of gallbladder disease and liver problems. Discontinue use and consult your healthcare provider if jaundice develops or worsens.

• Calcium Level Changes: Estrogen can alter blood calcium levels, with heightened risk in individuals with breast cancer that has metastasized to the bones.

• Vision Problems: Rarely, estrogens can cause vision issues due to clotting in the eyes. Any sudden vision changes require immediate medical attention.

• Triglyceride Levels: Estrogen can increase blood triglyceride levels, potentially leading to pancreatitis. Regular blood tests are advised.

• Fluid Retention: HRT can cause fluid retention, exacerbating conditions like heart failure or kidney damage.

• Exacerbation of Other Conditions: Estrogen therapies can worsen conditions such as high blood pressure, asthma, diabetes, migraines, and seizures. Prior medical history should be discussed with a healthcare provider.

• Drug Interactions: Some medications may affect the metabolism of Angeliq, altering its efficacy and side effects. Consult your healthcare provider about any other medications you are taking.

Contraindications:

• Do not use this medication if you have unexplained vaginal bleeding, a history of breast or estrogen-dependent cancers, a high risk of blood clots, or a history of blood clots, stroke, or heart attack.
• Avoid use if you have bleeding disorders, kidney or liver problems, Addison's disease, or if you have had a hysterectomy.

In case of overdose, seek emergency medical assistance immediately. Always discuss your health history and any concerns with your healthcare provider to ensure safe use of hormone therapies.

When taking this medication, you may experience some common side effects, which are generally mild and manageable. These include dizziness, lightheadedness, headaches, stomach upset, bloating, irritability, changes in sleep patterns, nausea, weight changes, and alterations in sexual interest. Some individuals might also notice changes in vaginal discharge or breast tenderness. If these symptoms persist or worsen, it's advisable to consult your healthcare provider for further guidance.

While the above side effects are more common, there are others that, although less frequent, should not be ignored. These include breast pain, vaginal bleeding, belly pain, migraines, vaginal yeast infections, diarrhea, and swelling in the lower legs or hands. Mood changes and the development of cervical polyps have also been reported. If you experience any of these, particularly if they are severe, contacting your healthcare provider is recommended.

There are also rare but serious side effects that require immediate medical attention. These include symptoms of a heart attack, such as chest pain, belly discomfort, sweating, nausea, and dizziness. A stroke may present as sudden numbness or weakness in the arm, leg, or face, confusion, trouble seeing, headache, or difficulty walking. Other serious conditions include deep vein thrombosis, pulmonary embolism, and liver or gallbladder problems, which may manifest as yellowing of the skin or eyes, unusual tiredness, or dark urine. Additionally, unusual vaginal bleeding, discharge, or pelvic pain should prompt urgent medical consultation.

Although a very serious allergic reaction to this drug is rare, be vigilant for signs such as a rash, itching or swelling, severe dizziness, or trouble breathing and seek medical help immediately should these occur. Always keep in touch with your healthcare provider if you notice any side effects not covered here.

When using Angeliq (drospirenone/estradiol), be aware of potential interactions with other medications or supplements. It's important to inform your doctor and pharmacist about all the drugs and supplements you take, whether they are prescription, over-the-counter, or herbal.

Certain medications should not be combined with Angeliq. These include boceprevir and Tranexamic Acid. Your doctor may need to consider alternative treatments or adjust your current medications.

Some drugs are generally not recommended to be used with Angeliq, but may be necessary in specific situations. If these drugs are prescribed together, your healthcare provider might need to adjust the dosage or frequency. These medications include, but are not limited to, abametapir, amifampridine, various antibiotics like Amoxicillin, Carbamazepine, Dexamethasone, and St. John's wort.

Additionally, using Angeliq with other medications might increase the risk of side effects, but the combination could be necessary for your treatment. In such cases, your doctor may alter the dosing or administration schedule. This group includes drugs like Amitriptyline, Atazanavir, Diazepam, and Warfarin.

Moreover, drospirenone, a component of Angeliq, can elevate potassium levels in your blood. Therefore, you must inform your doctor if you are consistently taking other medications that also increase potassium, such as Aliskiren, certain blood pressure drugs like ACE inhibitors and angiotensin receptor blockers, NSAIDs, and potassium-sparing diuretics.

Lastly, Angeliq may interact with medications that affect the metabolism of estrogen, which can alter its effectiveness. Examples include certain antifungals, macrolide antibiotics, and seizure medications. Always ensure that all healthcare providers and lab personnel are aware of your use of Angeliq to avoid any potential test inaccuracies.