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Hormone replacement therapy (HRT), whether estrogen-only or combined with progestin, carries certain risks if used after menopause. It is crucial to evaluate the advantages and risks of HRT with your healthcare provider, considering your personal health history.

• Avoid Using for Prevention: Combination HRT is not recommended for preventing heart disease or dementia.
• Potential Serious Side Effects: There is a rare risk of severe complications such as blood clots (leading to heart attack, stroke, or clots in the lungs or legs), dementia, and breast cancer. The likelihood of experiencing a stroke or developing breast cancer increases with age, particularly in women over 75.
• Cancer Risks: Estrogen use may elevate the risk of ovarian cancer.
• Duration and Dosage: The risks associated with HRT can be influenced by the duration of use and the estrogen dose. It is advised to use the therapy for the shortest time necessary and at the lowest effective dose to reduce the chance of serious side effects.
• Regular Consultations: Regularly review your treatment plan with your doctor, ideally every 3-6 months, to determine if continued use of the medication is necessary.
• Routine Physical Exams: If on prolonged therapy, ensure you undergo comprehensive physical exams regularly, typically once a year, or as directed by your doctor.

Please consult the Notes section for further details.

Taking this medication may lead to some common side effects such as dizziness, lightheadedness, headaches, stomach upset, bloating, irritability, changes in sleep patterns, nausea, weight fluctuations, altered sexual interest, changes in vaginal discharge, or breast tenderness. These effects are usually mild, but if they persist or worsen, it is important to consult your healthcare provider.

In some cases, more serious side effects may occur. Be vigilant for signs such as mood or mental changes, including depression or memory loss, breast lumps, nipple discharge, swelling in the hands or feet, or unusual vaginal bleeding. Additionally, watch for yellowing of the eyes or skin, stomach or abdominal pain, seizure worsening, muscle weakness, or indications of poor diabetes control like increased thirst and urination. Symptoms of high potassium levels, such as muscle weakness or an irregular heartbeat, should also be noted.

Rarely, this medication can cause serious blood clot issues, which may be life-threatening. Seek immediate medical attention if you experience pain, swelling, or warmth in the groin or calf, shortness of breath, chest, jaw, or left arm pain, unusual sweating, sudden dizziness, confusion, speech difficulties, weakness on one side of the body, sudden vision changes, or severe headaches.

Allergic reactions to this medication are uncommon but can be severe. Immediate medical help is necessary if you notice symptoms like rash, itching or swelling, severe dizziness, or trouble breathing. If you experience any side effects not mentioned here, contact your healthcare provider for advice.