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This medication comes with important safety information that users must consider to mitigate potential risks. The following points outline key precautions and steps to follow:

• Hepatitis B Worsening: If you have both hepatitis B and HIV, abruptly stopping this medication may exacerbate hepatitis B symptoms or lead to severe liver issues. Always consult your healthcare provider before discontinuing use. Your doctor may continue to monitor your liver function for several months after you stop taking the medication. Be vigilant for symptoms such as fever, tiredness, nausea, vomiting, dark urine, clay-colored stool, or yellowing of the skin or eyes, and inform your doctor immediately if these occur.

• Kidney Health: Delstrigo may cause kidney issues in some users, either shortly after starting the medication or over time. Avoid using other drugs that may harm the kidneys, such as high doses of NSAIDs like ibuprofen and naproxen. Regular laboratory tests are essential to monitor kidney health. Notify your healthcare provider if you experience swelling in the legs or feet, difficulty urinating, or confusion, and seek immediate advice if you encounter bone or muscle pain, or fractures, as these may indicate kidney problems.

• Drug Interactions: Ensure your healthcare team is aware of all medications and supplements you are taking. Consult your provider or pharmacist before starting any new medications, as interactions with Delstrigo can lead to side effects or impact its effectiveness, potentially resulting in HIV resistance.

• Bone Health: Delstrigo can reduce bone mineral density, potentially causing osteoporosis and increasing fracture risk. Calcium and vitamin D supplements might be beneficial for prevention. Your provider may recommend bone density tests if you have fractures or other risk factors.

• Immune Reconstitution Syndrome: The medication may cause inflammation as your immune system recovers and becomes more active in fighting infections. This condition, known as immune reconstitution syndrome, can be dangerous. Your healthcare provider might check for and treat underlying infections before you begin Delstrigo. Report any fever, breathing difficulties, or sudden health changes to your provider.

• Contraindications: Do not use this medication if you are taking substances that significantly alter its metabolism, including St. John's wort, certain antiseizure drugs, and some tuberculosis treatments. Always discuss with your healthcare provider if these conditions apply to you to avoid serious health risks.

Following these guidelines and maintaining open communication with your healthcare provider will help manage the risks associated with this medication effectively.

When taking this medication, some patients may experience dizziness, drowsiness, nausea, trouble sleeping, or unusual dreams. These are common side effects and often do not require medical attention unless they persist or worsen. If you notice any severe or unusual symptoms, such as unexplained weight loss, extreme tiredness, persistent muscle aches or weakness, severe headaches, or joint pain, it is important to seek medical attention promptly.

There is a possibility that as your immune system strengthens, it might begin to fight off existing infections, which could cause symptoms to reappear or new symptoms to develop. Severe side effects that require immediate medical help include vision changes, signs of infection (such as fever, chills, swollen lymph nodes, trouble breathing, or persistent cough), signs of an overactive thyroid, or symptoms of Guillain-Barre syndrome.

Some people might experience mental or mood changes, such as depression or anxiety. Symptoms of kidney issues, lactic acid buildup, liver problems, or pancreatitis also require immediate attention. Changes in body fat distribution can occur, and while the long-term effects are unclear, discussing this with your healthcare provider is advised. Tenofovir may contribute to bone loss, potentially increasing the risk of fractures.

A very serious allergic reaction to the drug is rare but requires urgent medical care if symptoms like rash, swelling, or difficulty breathing occur. Always consult with your healthcare provider about any persistent or severe side effects, and ensure regular monitoring if needed.

Certain medications may interact with this drug. For instance, Orlistat and Sorbitol can cause interactions, and drugs that affect the kidneys, like Adefovir, Cidofovir, or aminoglycosides (such as Amikacin and gentamicin), should be used cautiously. It is important not to take this medication alongside other products containing Lamivudine or tenofovir unless advised by your doctor. Additionally, doravirine should only be used with this medication if specifically recommended by your physician.

Some drugs can alter how doravirine/lamivudine/tenofovir is removed from your body, impacting its effectiveness. These include medications like apalutamide, Butalbital, enzalutamide, Mitotane, Rifampin, secobarbital, and St. John's wort, as well as certain seizure medications (such as Carbamazepine, Phenobarbital, Phenytoin, and Primidone).

Furthermore, this medication might affect certain laboratory tests, including urine cannabinoid tests, potentially leading to false results. Therefore, it is important to inform your healthcare providers and laboratory staff that you are taking this medication.