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This medication carries significant risks of abuse, addiction, and potentially fatal overdose. It may also induce severe respiratory issues. To minimize these risks, it is essential to use the smallest effective dose for the shortest duration possible, as directed by your healthcare provider.

Key Safety Information:

• Respiratory Risks: The likelihood of severe breathing problems is heightened at the start of treatment or when dosages are incorrect or exceeded.
• Substance Interactions: Concurrent use with alcohol or other sedatives can result in severe side effects, including death. Be aware of any drugs that might interfere with this medication's elimination from your body.
• Emergency Signs: Seek immediate medical attention if you experience symptoms such as slow or shallow breathing, extreme lightheadedness, severe drowsiness, dizziness, or difficulty waking up.
• Safe Storage: Store this medication securely to prevent theft, misuse, or accidental ingestion. Immediate medical assistance is required if someone accidentally ingests this drug.
• Pregnancy Precautions: Women of childbearing age should consult their healthcare provider about the risks and benefits. This medication is not advised during pregnancy, especially in the first two months, due to a slight risk of birth defects. Long-term use or high doses close to delivery may harm the unborn baby. Infants born to mothers using this medication long-term may suffer severe withdrawal symptoms. Contact a doctor immediately if you observe symptoms like persistent crying, slow/shallow breathing, irritability, shaking, vomiting, diarrhea, poor feeding, or difficulty gaining weight in a newborn.

When taking this medication, you may experience some mild side effects such as drowsiness, dizziness, lightheadedness, facial flushing, nausea, vomiting, or constipation. These symptoms are common and usually not a cause for concern. If they persist or worsen, consult a healthcare professional. To minimize dizziness and lightheadedness, rise slowly from sitting or lying positions.

While serious side effects are uncommon, be alert for symptoms like interrupted breathing during sleep, mood changes, irregular heartbeat, or difficulty urinating. These require prompt medical attention. An immediate medical response is necessary if you experience severe side effects such as seizures or symptoms of a serious allergic reaction, which may include rash, itching, swelling, severe dizziness, or trouble breathing.

Be aware that this medication metabolizes into morphine in the body, which can lead to severe side effects in some individuals, such as slow or shallow breathing, extreme drowsiness, difficulty waking up, or confusion. Seek immediate medical assistance if these occur.

Although rare, serious allergic reactions can happen. Look out for signs like rash, itching, swelling, or trouble breathing, and seek urgent medical care. This overview does not cover all possible side effects, so if you notice any other symptoms, contact a healthcare provider for advice.

This medication can interact with certain drugs, including cimetidine, naltrexone, and samidorphan. It’s important to review your medications to ensure you’re not using multiple products containing guaifenesin, as it is available in both prescription and over-the-counter forms. The risk of severe side effects, like slow or shallow breathing and extreme drowsiness or dizziness, may increase if this drug is combined with others that also cause drowsiness or breathing difficulties. Inform your healthcare provider if you are taking other opioid medications (such as morphine or hydrocodone), alcohol, marijuana, sleep or anxiety medications (such as alprazolam or lorazepam), muscle relaxants (such as carisoprodol or cyclobenzaprine), or antihistamines (such as cetirizine or diphenhydramine).

Be sure to check the labels on all your medications, especially those for allergies or cough and cold, as they may contain ingredients that induce drowsiness. Consult your pharmacist about safely using these products. Additionally, some medications can affect how guaifenesin/codeine is processed by your body, altering its effectiveness. These include azole antifungals (like ketoconazole), bupropion, fluoxetine, macrolide antibiotics (such as erythromycin), paroxetine, quinidine, rifamycins (such as rifabutin, rifampin), ritonavir, and certain seizure medications (such as carbamazepine, phenytoin).

This drug may also interfere with certain laboratory tests, potentially leading to incorrect results. Ensure that lab staff and all your healthcare providers are aware that you are taking this medication.