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Codeine is associated with potential abuse and addiction, which can result in overdose and potentially fatal outcomes. It can also lead to serious breathing difficulties. To minimize these risks, it is essential to use the smallest effective dose for the briefest duration possible, as directed by your healthcare provider.

Key Points to Consider:

• Opioid Overdose Preparedness: Consult your doctor or pharmacist about having naloxone on hand to address potential opioid overdose. Ensure your family or household members are informed about opioid overdose symptoms and how to respond.

• Breathing Risks: The likelihood of severe breathing issues is heightened when beginning treatment, after a dosage increase, or if an incorrect dose is taken. Combining codeine with alcohol or other sedatives can lead to severe side effects, including death.

• Drug Interactions: Certain medications may interfere with how codeine is processed by your body, altering its effectiveness. Be informed about which substances should be avoided while taking codeine.

• Emergency Symptoms: Seek immediate medical attention if you experience slow or shallow breathing, unusual lightheadedness, severe drowsiness or dizziness, or difficulty waking up.

• Storage and Safety: Store codeine securely to prevent theft, misuse, or abuse. In case of accidental ingestion, obtain medical assistance immediately.

• Pregnancy Precautions: Women of childbearing age should discuss risks and benefits with their healthcare provider. If pregnant or planning to become pregnant, inform your doctor. Codeine should only be used during pregnancy when clearly necessary, as it may slightly increase the risk of birth defects if used in the early months. Prolonged or high-dose usage near delivery may harm the baby, and newborns exposed to codeine over extended periods may exhibit withdrawal symptoms.

• Pediatric Use: Codeine is not recommended for children under 18, as it can cause serious breathing problems, especially in those who are obese, have breathing disorders, or have undergone certain surgeries. Discuss the risks and benefits with your healthcare provider.

You might experience some mild side effects, such as nausea, vomiting, constipation, lightheadedness, dizziness, drowsiness, or sweating. These are generally manageable but should be discussed with a healthcare professional if they persist or worsen. To alleviate constipation, consider increasing your dietary fiber intake, drinking plenty of water, and staying active. A pharmacist can also advise on suitable laxatives if needed. To minimize dizziness or lightheadedness, rise slowly from sitting or lying down.

Serious side effects are uncommon, but it's important to be vigilant. Contact your healthcare provider immediately if you experience symptoms like sleep apnea, mental or mood changes (including agitation, depression, or hallucinations), stomach or abdominal pain, difficulty urinating, irregular heartbeat, vision changes, or signs of adrenal gland issues such as appetite loss, fatigue, or weight loss.

In rare cases, very serious side effects may occur due to rapid conversion of codeine to morphine in the body. Seek urgent medical attention if you notice slow or shallow breathing, severe drowsiness, difficulty waking up, or confusion. Additionally, although uncommon, allergic reactions can happen. Look out for symptoms like rash, itching, swelling of the face, tongue, or throat, severe dizziness, or trouble breathing, and seek immediate medical care.

This list is not exhaustive. If you notice any other unusual symptoms, contact a healthcare professional for advice.

Some medications that may interact with this drug include specific pain relievers like Butorphanol, Nalbuphine, pentazocine, as well as Naltrexone and samidorphan. Taking this medication with others that induce drowsiness or respiratory issues can heighten the risk of serious side effects such as slow or shallow breathing and severe drowsiness or dizziness. Inform your doctor or pharmacist if you are using other opioid pain or cough medications, such as morphine or hydrocodone, or if you consume alcohol, marijuana, sleep or anxiety medications like Alprazolam, Lorazepam, or Zolpidem, muscle relaxants like Carisoprodol or Cyclobenzaprine, or antihistamines like Cetirizine or diphenhydramine. Always check the labels on your other medicines, including allergy or cough and cold products, as they might contain ingredients that cause drowsiness. Consult your pharmacist about the safe use of these products.

Additionally, some drugs can affect how codeine is removed from your body, influencing its effectiveness. These include azole antifungals like Ketoconazole, bupropion, Fluoxetine, macrolide antibiotics such as Erythromycin, paroxetine, quinidine, rifamycins like Rifabutin or Rifampin, Ritonavir, and certain seizure medications like Carbamazepine and Phenytoin. This medication might also interfere with lab tests such as amylase or lipase levels, potentially causing incorrect results. Ensure that lab personnel and all your healthcare providers are aware that you are taking this drug.