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Quetiapine (Seroquel) is prescribed for certain mental health conditions, including schizophrenia and bipolar disorder. While it can be effective, it is important to be aware of the potential risks and necessary precautions associated with its use. Below is a summary of key safety information and warnings:

• Increased Risk in Older Adults with Dementia: Older individuals (65 years and above) with dementia-related psychosis who take quetiapine may face a heightened risk of serious side effects or death. This medication is not approved for such conditions. Discuss any dementia-related symptoms with your healthcare provider before starting quetiapine.

• Mental Health Changes and Suicidal Thoughts: There is a risk of worsening depression and suicidal thoughts, especially in individuals younger than 25, during the initial weeks of treatment or when changing the dose. Monitor for unusual mood changes, anxiety, or impulsive behavior, and seek immediate medical attention if such symptoms occur.

• Neuroleptic Malignant Syndrome: Quetiapine can trigger a rare but life-threatening condition characterized by fever, muscle stiffness, and confusion. If you experience these symptoms, stop taking the medication and seek urgent medical care.

• Metabolic Changes: The medication can lead to increased blood sugar, cholesterol levels, and weight gain. Regular monitoring of these levels through blood tests is advised. Maintaining a healthy diet and exercise routine is recommended.

• Movement Disorders: Prolonged use of quetiapine can cause uncontrollable body movements. Report any such symptoms to your healthcare provider promptly, as they can become permanent if untreated.

• Blood Pressure and Fall Risk: Quetiapine may cause low blood pressure and increase the risk of falls. Rise slowly from sitting or lying positions and contact your provider if you experience falls or dizziness.

• White Blood Cell Count: The medication can lower white blood cell counts, increasing infection risk. Regular blood tests will monitor your levels. Report any signs of infection, such as fever or persistent cough, to your provider.

• Heart Rhythm Changes: Quetiapine can affect heart rhythm, posing serious risks. Seek immediate medical attention if you experience chest pain, fainting, or palpitations.

• Seizure Risk: Inform your provider about any history of seizures before starting quetiapine, as it may increase seizure risk.

• Thyroid and Prolactin Levels: Quetiapine can affect thyroid function and increase prolactin levels, leading to various health issues. Regular monitoring of hormone levels may be necessary.

• Cognitive and Sedative Effects: The medication can cause drowsiness and affect concentration. Avoid driving or operating machinery until you understand how quetiapine affects you. Be cautious with alcohol and other sedatives.

• Emergency Action for Overdose: In the event of an overdose, seek emergency medical assistance immediately.

Discuss all potential risks and benefits with your healthcare provider, especially if you have pre-existing health conditions or are taking other medications. Your safety is a priority, so ongoing communication with your healthcare provider is essential while using quetiapine.

Common side effects:

• Headache
• Agitation
• Sleepiness
• Dizziness
• Dry mouth
• Constipation
• General pain

Less common but important to monitor:

• Difficulty controlling muscle movements
• Weight gain
• Increased sleepiness

Serious side effects:

• Fast heart rate
• Uncontrollable vomiting
• Severe weakness
• Indigestion
• Fatigue
• Increased blood sugar levels
• Increased cholesterol
• Neuroleptic malignant syndrome
• Tardive dyskinesia
• Increase in prolactin levels
• Allergic reaction
• Painful, prolonged erection

Interactions with high risk of serious adverse effects and should be avoided:

• Bepridil
• Bromopride
• Cisapride
• Dronedarone
• Fluconazole
• Lefamulin
• Mesoridazine
• Metoclopramide
• Pimozide
• Piperaquine
• Posaconazole
• Saquinavir
• Sparfloxacin
• Terfenadine
• Thioridazine
• Ziprasidone

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Amiodarone
• Moxifloxacin
• Procainamide
• Quinidine
• Sotalol
• Itraconazole
• Ketoconazole
• Phenytoin
• Codeine
• Hydrocodone
• Alprazolam
• Lorazepam
• Carisoprodol
• Cyclobenzaprine
• Cetirizine
• Diphenhydramine