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Antidepressant medications are prescribed to manage conditions such as depression and other mental or mood disorders. While they offer significant benefits, they also come with potential risks that should be carefully considered.

• Individuals, particularly those under 25, may experience an increase in depression or other mental health symptoms, including suicidal thoughts or behaviors, when taking antidepressants.
• It is crucial to consult with a healthcare provider about the risks and benefits of using these medications, especially for younger patients, regardless of whether the treatment is for a mental or mood disorder.
• Any signs of worsening depression, sudden changes in behavior, or the emergence of suicidal thoughts should be reported to a healthcare provider immediately. This includes new or escalating anxiety, panic attacks, difficulty sleeping, irritability, anger, impulsivity, severe restlessness, or unusually rapid speech.
• Be particularly vigilant for these symptoms when starting a new antidepressant or adjusting the dosage.
• For older adults with dementia, there is a slightly elevated risk of severe, potentially life-threatening side effects such as stroke, heart failure, irregular heartbeat, or pneumonia. Antidepressants are not approved for treating dementia-related behavioral issues.
• Discuss alternative treatments and the associated risks and benefits with a healthcare professional for managing dementia-related behavior concerns.

In case of an overdose, seek emergency medical attention promptly.

When taking this medication, you might experience dizziness, lightheadedness, drowsiness, diarrhea, dry mouth, constipation, increased appetite, weight gain, or trouble sleeping. These are usually mild, but if they persist or worsen, inform your healthcare provider. To reduce the risk of dizziness-related falls, rise slowly from sitting or lying positions.

Be aware of more severe side effects that require immediate medical attention. These include unusual mental or mood changes, swelling of hands or feet, restlessness, tremors, changes in sexual function, trouble urinating, easy bruising, muscle spasms, yellowing of the skin or eyes, severe stomach pain, slow heartbeat, and interrupted breathing during sleep.

Very serious side effects include black stools, vomit resembling coffee grounds, severe headaches, seizures, eye problems, or vision changes. In rare cases, this medication can increase blood sugar levels, potentially leading to or worsening diabetes, and may also raise cholesterol levels, especially in teens.

This drug may also elevate serotonin levels, occasionally leading to serotonin syndrome, characterized by symptoms like a fast heartbeat, hallucinations, loss of coordination, severe dizziness, nausea, vomiting, twitching muscles, or unexplained fever. Additionally, it may cause neuroleptic malignant syndrome (NMS), with symptoms such as fever, muscle stiffness, severe confusion, and dark urine.

Rarely, it can cause tardive dyskinesia, marked by unusual movements, or increase prolactin levels, affecting menstrual cycles in females or sexual function in males. Very rarely, males may experience a prolonged erection; seek immediate help if this occurs. Lastly, although rare, serious allergic reactions can happen, requiring urgent medical care for symptoms like rash, swelling, or trouble breathing. Always keep your healthcare provider informed of any side effects you experience.

Fluoxetine, a component of this medication, can linger in your body for several weeks after your last dose, potentially interacting with various other drugs. If you've used this medication within the past five weeks, consult your doctor or pharmacist before starting any new medicine. Interactions may occur with drugs like Fosamprenavir/Ritonavir, metoprolol, diuretics (e.g., Furosemide), medications that increase bleeding risk (such as antiplatelet drugs like Clopidogrel, NSAIDs like Ibuprofen/Naproxen, anticoagulants like Dabigatran/Warfarin), blood pressure medications, and treatments for Parkinson's disease (e.g., Cabergoline).

Combining MAO inhibitors with this medication can lead to a severe, possibly life-threatening reaction. Avoid using MAO inhibitors (like isocarboxazid, Linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, Tranylcypromine) during treatment, and for most, avoid starting them two weeks before and five weeks after finishing this medication. Consult your doctor for specific guidance on when to begin or cease use.

This medication may slow down the elimination of other drugs from your body, affecting their effectiveness. This includes medicines such as Cimetidine, Phenytoin, Pimozide, vinblastine, certain antipsychotics (like Aripiprazole, Clozapine, Haloperidol, Perphenazine, Thioridazine), antiarrhythmics (such as Propafenone, Flecainide), and tricyclic antidepressants (like Desipramine, imipramine).

Using Aspirin with this medication may increase bleeding risk. However, if your doctor has advised you to take low-dose aspirin (81-162 milligrams daily) to prevent heart attacks or strokes, continue unless directed otherwise. Discuss with your doctor or pharmacist for more details.

The chance of developing serotonin syndrome/toxicity rises if you take other serotonin-increasing drugs, such as street drugs like MDMA/"ecstasy," St. John's wort, certain antidepressants (other SSRIs like Citalopram/paroxetine, SNRIs like Duloxetine/Venlafaxine), and Tryptophan. This risk is higher when starting or increasing doses of these medications.

Inform your doctor or pharmacist if you are using other products that cause drowsiness, like opioid pain relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), sleep or anxiety medications (such as Alprazolam, Lorazepam, Zolpidem), muscle relaxants (like Carisoprodol, Cyclobenzaprine), or antihistamines (such as Cetirizine, diphenhydramine).

Check all medication labels (including those for allergies or cold remedies) as they may contain drowsiness-inducing ingredients. Consult your pharmacist for safe usage.

Smoking may reduce the blood levels of this medication. Inform your doctor if you smoke or have recently quit.

This medication might interfere with certain medical or lab tests (e.g., brain scans for Parkinson's disease), potentially causing inaccurate results. Ensure all your healthcare providers and lab personnel are aware of your medication use.