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When taking this medication, you might experience mild side effects like nausea, vomiting, diarrhea, stomach pain or cramping, and loss of appetite. These can often be reduced by consuming the medication with food. If these symptoms persist or worsen, it's important to inform your healthcare provider.

While serious side effects are less common, be vigilant for signs such as persistent vomiting or nausea, yellowing of the eyes or skin, dark urine, severe stomach pain, unusual fatigue, muscle weakness, trouble speaking, blurred vision, drooping eyelids, or hearing loss. These could indicate liver issues and need prompt medical attention.

In rare situations, this medication may lead to severe intestinal issues caused by C. difficile bacteria. Symptoms like persistent diarrhea, abdominal pain, or blood/mucus in the stool should be reported to your doctor immediately. Avoid using anti-diarrhea or opioid products if these symptoms occur, as they might worsen the condition.

Prolonged use of the medication might lead to oral thrush or yeast infections. Be aware of symptoms such as white patches in the mouth or changes in vaginal discharge, and notify your doctor if they arise. Although a severe allergic reaction is rare, seek emergency medical help if you experience a rash, itching, swelling of the face, tongue, or throat, severe dizziness, or trouble breathing.

This summary doesn't cover all possible side effects. If you notice other unusual symptoms, reach out to your healthcare provider for advice.

Erythromycin may interact with several other drugs, potentially altering their effectiveness. One such medication is digoxin. Additionally, erythromycin, along with other drugs, can affect heart rhythm by causing QT prolongation. This includes drugs like amiodarone, dofetilide, pimozide, procainamide, propafenone, quinidine, and sotalol.

Certain medications may influence the way erythromycin is eliminated from the body, which can change how it works. These include azole antifungals (such as itraconazole and ketoconazole), certain calcium channel blockers (like diltiazem and verapamil), and specific anti-seizure drugs (such as carbamazepine and phenytoin).

Conversely, erythromycin can slow down the elimination of other medications, potentially affecting their action. This includes drugs like bromocriptine, colchicine, certain benzodiazepines (such as midazolam and triazolam), eletriptan, ergot alkaloids (such as ergotamine and dihydroergotamine), medications for erectile dysfunction or pulmonary hypertension (like sildenafil and tadalafil), certain statins (such as lovastatin and simvastatin), and vinblastine.

Furthermore, erythromycin may interfere with specific laboratory tests, such as urine tests, leading to inaccurate results. It is essential to inform laboratory staff and all healthcare providers that you are taking this medication.