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When considering the use of Symtuza, it is essential to be aware of potential safety concerns and warnings. This medication can pose specific risks, and certain precautions should be taken to ensure safe usage. Below, you will find critical safety information related to Symtuza:

• Worsening of Hepatitis B Infection: If you have both HIV and hepatitis B, stopping Symtuza can lead to a severe flare-up of hepatitis B, potentially causing liver function deterioration or liver failure. Your healthcare provider will check for hepatitis B before starting treatment and monitor your liver tests after discontinuation.

• Liver Problems and Lactic Acidosis: Rarely, Symtuza users may experience liver issues, such as fatty liver and inflammation, and a dangerous increase in blood lactic acid levels, known as lactic acidosis. These are serious conditions that require immediate medical attention.

• Severe Skin and Allergic Reactions: The darunavir component in Symtuza can cause severe skin reactions, particularly in individuals with sulfa allergies. Rashes, which may be mild or moderate, have occurred within the first four weeks of treatment.

• Overactive Immune System: Symtuza can trigger an intense immune response, known as immune reconstitution syndrome, as the body starts combating previously uncontrolled infections. This can lead to significant inflammation.

• Kidney Problems: Some patients have experienced kidney issues shortly after beginning treatment. Avoid combining Symtuza with other kidney-harming medications, such as high doses of NSAIDs, especially if you have a history of kidney problems.

• Changes in Body Fat: Rare changes in body fat distribution have been observed in individuals using HIV medications like Symtuza. These changes can involve fat accumulation in specific areas and fat loss in others. Notify your healthcare provider if you notice such changes.

• Bleeding in Hemophilia Patients: Those with hemophilia may experience increased bleeding when taking Symtuza. If bleeding occurs, consult your healthcare provider. The relationship between Symtuza and increased bleeding incidents is not fully understood.

• Drug Interactions: Symtuza may interact with various medications, including certain HIV and anti-seizure drugs, potentially reducing effectiveness or increasing side effect risks. Discuss all medications you are taking with your healthcare provider to prevent harmful interactions.

For individuals with contraindications, such as taking medications that may interact adversely with Symtuza, it is crucial to consult with a healthcare professional before starting treatment. Always communicate openly with your healthcare provider about any concerns or symptoms you experience while taking Symtuza.

This medication can cause a variety of side effects, some common and mild, while others are rare and potentially serious. Common side effects include diarrhea, rash, nausea, fatigue, and headaches. These symptoms are usually mild, but if they persist or worsen, it is advisable to consult a healthcare provider.

Other reported side effects include belly discomfort and excess gas. These are generally not serious but should be discussed with a healthcare provider if they become bothersome.

Serious side effects, though rare, require immediate medical attention. These include lactic acidosis, which may present as unusual tiredness or weakness, abdominal pain, muscle pain, or breathing difficulties. Kidney problems can manifest as fatigue, confusion, nausea, reduced urination, leg swelling, or joint pain. Liver issues might show up as nausea, vomiting, loss of appetite, pain in the right side of the abdomen, yellowing of the skin or eyes, dark urine, or light-colored stool.

Severe allergic reactions are also rare but serious, and symptoms may include facial swelling, hives, rash, itchy skin, blistering or peeling skin, body aches, and difficulty breathing. Additionally, changes in body fat distribution can occur, with increased fat in the upper back and stomach areas and decreased fat in the arms and legs.

It is also important to be aware that this medication can sometimes cause a rash, which is often not serious. However, if accompanied by fever, fatigue, muscle or joint pain, blisters, mouth sores, or red/swollen eyes, seek medical attention immediately. Always consult your healthcare provider if you experience any other unusual symptoms.

This medication can interact with other drugs, so it's important to be aware of potential interactions. Avoid taking it with adefovir and orlistat. Additionally, do not use this medication alongside other HIV treatments such as ritonavir, or with products containing cobicistat, darunavir, emtricitabine, or tenofovir.

The medication may slow the removal of certain drugs from your system, potentially altering their effectiveness. This includes medications like dronedarone, eletriptan, eplerenone, ergot alkaloids (like ergotamine and dihydroergotamine), lomitapide, pimozide, ranolazine, rivaroxaban, salmeterol, tolvaptan, specific alpha blockers (such as alfuzosin and tamsulosin), certain benzodiazepines (like midazolam and triazolam), some statins (like lovastatin and simvastatin), and drugs for erectile dysfunction or pulmonary hypertension (such as avanafil and sildenafil).

Conversely, some drugs can affect how this medication is removed from your body, which might influence its effectiveness. These include apalutamide, mitotane, certain rifamycins (like rifampin and rifapentine), St. John's wort, and medications for seizures (such as carbamazepine, oxcarbazepine, phenobarbital, phenytoin, and primidone).

This medication may reduce the effectiveness of hormonal birth control methods like pills, patches, or rings, potentially leading to pregnancy. It may also increase some side effects of hormonal contraceptives. Discuss alternative reliable birth control methods with your doctor, and use barrier protection (such as latex or polyurethane condoms/dental dams) during sexual activity to decrease the risk of HIV transmission. Notify your doctor if you experience new spotting or breakthrough bleeding, as these could indicate that your hormonal birth control is not functioning effectively.