Top 12 Rheumatoid Arthritis Prescriptions

By: Noah W Chung | PharmD

Rheumatoid arthritis is a chronic autoimmune condition that affects the joints, causing inflammation, stiffness, and pain. Patients searching for popular rheumatoid arthritis prescriptions are often seeking guidance on effective treatments, potential side effects, and medication options that fit their lifestyle and budget. Because many RA medications, especially biologics and specialty drugs, can be costly, platforms like SaveHealth.com help patients compare pharmacy prices and find more affordable options for ongoing therapy.

This article reviews twelve of the most commonly prescribed RA medications, their benefits, and what to consider when selecting a treatment plan.

How Rheumatoid Arthritis Medications Work

Medications for RA are designed to reduce inflammation, slow disease progression, and prevent joint damage. They work through different mechanisms depending on the drug class.

Major RA medication categories

• DMARDs (Disease-Modifying Anti-Rheumatic Drugs): Slow disease progression. Examples: Methotrexate (Trexall, Xatmep, Rasuvo, Jylamvo, Otrexup, RediTrex, Rheumatrex), Leflunomide (Arava), Sulfasalazine (Azulfidine) and Hydroxychloroquine (Plaquenil).

• Biologics:

  • TNF-alpha inhibitors (most common first line biologic): Humira (Adalimumab), Enbrel (Etanercept), Remicade (Infliximab), Simponi (Golimumab), Cimzia (Certolizumab)

  • T-cell Co-stimulation Modulators: Orencia (Abatacept)

  • IL-6 Inhibitors: Actemra (Tocilizumab)

  • B-cell Depleters: Rituxan (Rituximab)

  • IL-1 Receptor Antagonist: Kineret (Anakinra)

  Target specific pathways of the immune system to reduce inflammation. There are many types of biologics that are used that affect different pathways of the immune system to treat RA. Theses include:

• NSAIDs (Non-Steroidal Anti-Inflammatory Drugs):Reduce pain and inflammation but do not alter disease progression. Examples: Mobic (Meloxicam), Naprosyn (Naproxen), Voltaren (Diclofenac), and Celebrex (Celecoxib)

• Corticosteroids:Provide rapid symptom relief during flare-ups but are not intended for long-term disease control. Example: Prednisone

• JAK (Janus Kinase) Inhibitors: Block the activation of STAT proteins which are responsible for the inflammation and joint damage seen in RA, effectively reducing pain and swelling. Examples: Xeljanz (Tofacitinib), Olumiant (Baricitinib), and Rinvoq (Upadacitinib)

Cost can influence the choice of therapy. SaveHealth.com allows patients to compare prices for these medications to ensure long-term affordability.

Top 12 Rheumatoid Arthritis Medications

Here is a list of the most commonly prescribed RA medications, including both traditional and newer options.

1. Xatmep (Methotrexate)

An oral solution form of methotrexate often used for pediatric RA, Xatmep reduces inflammation and slows joint damage. Typically adults will use the oral tablet form of methotrexate instead of the oral solution due to stability and cost.

2. Arava (Leflunomide)

A DMARD that works for adults who cannot tolerate methotrexate. It helps control disease activity and inflammation.

3. Xeljanz (Tofacitinib)

The first FDA approved JAK inhibitor for the treatment of RA. All JAK inhibitors are effective and powerful in treating RA, however safety warnings due to the risk of infections prevent them from being first-line treatment options.

4. Rasuvo

An injectable methotrexate option, Rasuvo allows for convenient self-administration with reduced gastrointestinal side effects.

5. Humira (Adalimumab)

Humira is a good secondary option since treatment usually starts with traditional DMARDs like methotrexate. Patients often experience decreased joint pain, swelling and stiffness, which can help to improve their quality of life.

6. Celebrex (Celecoxib)

FDA approved to treat pain and inflammation associated with rheumatoid arthritis in adults and juvenile rheumatoid arthritis. This medication may help manage symptoms such as joint pain, swelling and stiffness, but does not cure the disease or prevent joint damage.

7. Kineret (Anakinra)

A biologic that targets the IL-1 receptor, Kineret is typically used for patients with moderate to severe RA, particularly if other treatments have failed.

8. Mobic

Also known as meloxicam, Mobic is an NSAID used to reduce pain and inflammation. It is available in oral form and offers convenient administration since it is typically taken once daily.

9. Plaquenil (hydroxychloroquine)

Its mechanism involves modulating the immune system to decrease inflammation, which in turn helps alleviate joint pain and stiffness and may contribute to preventing long-term joint damage. It is advised to take with food or milk to minimize potential stomach upset.

10. Naprosyn (Naproxen)

A widely used NSAID that reduces pain, swelling, and stiffness. Available over the counter or by prescription.

11. Orencia (Abatacept)

Orencia is a biologic (T-cell co-stimulation modulator) for adults with moderately to severely active Rheumatoid Arthritis. It can be given as a weekly subcutaneous injection or monthly IV-infusion which helps reduce joint pain, swelling, and damage.

12. Rituxan (Rituximab)

Rituxan is a monoclonal antibody specially identified under the class of drugs known as a B-cell depleters. It is typically used in combination with methotrexate specifically when other treatments have failed such as “TNF-alpha inhibitors” (e.g., Humira, Enbrel).

Rheumatoid Arthritis Medication Comparison Table

Many of these medications, especially biologics and specialty DMARDs, can be expensive. SaveHealth.com allows patients to compare pharmacy prices to find the most cost-effective options.

Common Side Effects of Rheumatoid Arthritis Medications

Side effects depend on the type of medication, dose, and individual patient factors.

DMARDs

• Nausea, diarrhea, loss of appetite, stomach pain

• Hair loss

• Liver enzyme elevation **requires monitoring**

• Flu like symptoms, fatigue

Biologics

• Nausea and or abdominal pain

• Headache

• Increased risk of infections

• Injection site reactions (redness, pain, itching)

NSAIDs

• Stomach upset

• Kidney issues **typically documented with long-term or high-dose use**

• Increased bleeding risk

JAK Inhibitors

• Upset stomach

• Headache / fatigue

• Acne

• Elevated cholesterol / liver enzymes

• Infections

Corticosteroids

• Weight gain

• Bone loss

• Mood changes

Switching medications or adjusting doses can often reduce side effects. Cost considerations during these changes can be managed using SaveHealth.com to find lower-priced alternatives.

Choosing the Right Rheumatoid Arthritis Medication

Selecting an RA medication requires balancing disease control, side effect tolerance, convenience, and cost.

Factors to consider

• Severity of RA and symptom flare-ups

• Previous response to medications

• Risk of side effects

• Preferred administration method (oral vs injection)

• Insurance coverage and out-of-pocket cost

SaveHealth.com helps patients check pharmacy prices and explore more affordable options for both DMARDs and NSAIDs, making consistent long-term therapy more feasible.

Tips for Managing Rheumatoid Arthritis Medication Costs

RA medications, particularly biologics and specialty DMARDs, can be expensive. Strategies to manage costs include:

• Comparing pharmacy prices online using SaveHealth.com

• Considering generic options like meloxicam or naproxen

• Exploring manufacturer savings programs

• Reviewing insurance coverage and co-pay assistance options

• Planning prescription refills to avoid gaps in therapy

Even small savings per month can add up, making cost comparison a practical step in long-term RA management.

Rheumatoid Arthritis Prescriptions

Rheumatoid arthritis management includes a range of medications, from traditional DMARDs to NSAIDs and biologics. Understanding the differences between Xatmep, Leflunomide, Arava, Rasuvo, Ridaura, Vazalore, Kineret, Mobic, Meloxicam, Naproxen, Naprosyn, and Cambia helps patients choose the most effective treatment for their condition. Since medication costs vary widely, using tools like SaveHealth.com ensures patients can access necessary therapies without financial strain. Working closely with a healthcare provider while considering effectiveness, safety, and affordability is key to achieving the best long-term outcomes.

Note: This article is intended for informational purposes only and does not substitute professional medical advice. Always consult with a qualified healthcare provider for diagnosis and treatment options.

References

• Johns Hopkins Arthritis Center. Rheumatoid Arthritis Treatment. https://www.hopkinsarthritis.org/arthritis-info/rheumatoid-arthritis/ra-treatment/

• Healthgrades. 10 Drugs Commonly Prescribed for Rheumatoid Arthritis. https://resources.healthgrades.com/right-care/rheumatoid-arthritis/10-drugs-commonly-prescribed-for-rheumatoid-arthritis

• Healthline. Medications for Rheumatoid Arthritis. https://www.healthline.com/health/rheumatoid-arthritis/medications-list

• NHS. Rheumatoid Arthritis Treatment Options. https://www.nhs.uk/conditions/rheumatoid-arthritis/treatment/

• Rinvoq. Rheumatoid Arthritis Medication Information. https://www.rinvoq.com/rheumatoid-arthritis