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Using hormonal birth control, like the pill, patch, or ring, while smoking can significantly increase the risk of serious cardiovascular issues, such as stroke, heart attack, blood clots, and high blood pressure. These risks are amplified with age and the number of cigarettes smoked.

• It is advised to avoid smoking or using tobacco products while on this medication.
• Individuals over 35 years old who smoke or use tobacco should not use this medication.

When taking this medication, you might experience mild side effects such as nausea, vomiting, headaches, or abdominal discomfort like bloating and cramps. Some individuals also report breast tenderness, fluid retention leading to ankle or foot swelling, and changes in weight. It's common to experience spotting or irregular periods, particularly in the initial months. If these issues persist or worsen, consult your healthcare professional.

More serious side effects require immediate attention. These include unusual or severe vaginal bleeding patterns, symptoms indicating high potassium levels such as muscle weakness or an irregular heartbeat, and elevated blood pressure. Monitor your blood pressure regularly and report any concerns.

In rare cases, this medication can lead to severe complications like blood clots, resulting in symptoms such as chest pain, difficulty breathing, sudden headaches, or dizziness. If you experience any of these, seek urgent medical care. Also, be aware of signs that might indicate liver issues, such as dark urine or yellowing of the skin, and report any mental health changes, including depression.

Allergic reactions to this medication are uncommon but serious. Look out for symptoms like rash, swelling, especially of the face or throat, severe dizziness, or trouble breathing, and seek immediate medical help if they occur. This summary covers common and severe reactions, but if you notice any other unusual effects, reach out to your healthcare provider.

Certain medications can interact with this drug. These include aromatase inhibitors like Anastrozole and Exemestane, Atazanavir combined with cobicistat, fezolinetant, ospemifene, Tamoxifen, Tizanidine, Tranexamic Acid, and specific treatments for chronic hepatitis C, such as the combination of ombitasvir, paritaprevir, and Ritonavir, with or without dasabuvir.

Drospirenone may increase potassium levels in your blood. If you are regularly using other medications that can also raise potassium levels, inform your doctor. These include Aliskiren, ACE inhibitors (like Enalapril and Lisinopril), angiotensin receptor blockers (such as Losartan and Valsartan), heparin, NSAIDs (such as Ibuprofen and Naproxen), and potassium-sparing diuretics (like Eplerenone, Spironolactone, and Triamterene).

Certain drugs can reduce the effectiveness of hormonal birth control by lowering the hormone levels in your body, which could lead to pregnancy. Examples include griseofulvin, Modafinil, rifamycins (such as Rifampin), ritonavir, St. John's wort, some seizure medications (such as barbiturates, Carbamazepine, Felbamate, Phenytoin, Primidone, Topiramate), and certain HIV medications (like nelfinavir and Nevirapine). Consult your doctor or pharmacist for more information.

Inform your doctor whenever you begin any new medication, and discuss whether you need to use an additional form of birth control. Notify your doctor if you experience any new spotting or breakthrough bleeding, as these could indicate that your birth control is not working effectively.

This medication may influence the results of certain lab tests. Ensure that lab personnel and all your healthcare providers are aware that you are taking this medication.