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Diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), is associated with several potential risks and requires careful consideration before use. Below are important safety warnings and precautions to keep in mind:

• Cardiovascular Risks: Diclofenac can increase the risk of heart attack and stroke, particularly with prolonged use. Individuals with a history of heart disease or those undergoing heart bypass surgery (CABG) are at an elevated risk. It's advisable to use the lowest effective dose for the shortest duration possible. Avoid use immediately before or after heart bypass surgery.

• Gastrointestinal Bleeding: This medication may lead to severe bleeding in the stomach or intestines, often without warning. The risk is higher for older adults and those with a history of ulcers or gastrointestinal bleeding. Be alert for symptoms such as persistent stomach pain, black/tarry stools, or vomit resembling coffee grounds.

• Heart Failure and Blood Pressure: Diclofenac can exacerbate heart failure symptoms and raise blood pressure. Patients with a history of heart-related issues should consult their healthcare provider to weigh the benefits and risks and monitor their condition regularly.

• Kidney Function: The use of diclofenac may impair kidney function or cause permanent damage, especially in individuals with pre-existing kidney conditions, dehydration, or heart failure. Symptoms like irregular heartbeat, reduced urine output, or confusion should be reported to a healthcare provider.

• Liver Concerns: Diclofenac can affect liver health. Regular monitoring through blood tests is recommended. Report symptoms such as nausea, fatigue, yellowing of the skin or eyes to a healthcare provider.

• Allergic Reactions: Those with known allergies to aspirin or other NSAIDs should exercise caution, as diclofenac may trigger similar reactions. Seek immediate medical help if you experience hives, difficulty breathing, or facial swelling.

• Severe Skin Reactions: Rare but serious skin reactions, including rashes and blisters, are possible. Discontinue use and consult a healthcare provider if such symptoms occur.

• Pregnancy Concerns: Diclofenac is not recommended during pregnancy, particularly after 20 weeks, due to potential harm to the unborn child. Pregnant individuals should explore safer alternatives with their healthcare provider.

• Anemia Risk: Diclofenac may cause or worsen anemia due to increased bleeding risk. Monitor for symptoms like fatigue and dizziness, and consider regular blood tests.

• Use and Storage: Diclofenac patches should be stored securely and disposed of properly to prevent accidental exposure, especially to children and pets. Avoid contact with eyes; rinse immediately with water if contact occurs.

• Drug Interactions: Avoid combining diclofenac patches with other oral NSAIDs unless advised by a healthcare provider, as this can increase the risk of bleeding and kidney issues.

Always consult your healthcare provider for personalized advice and report any unusual symptoms or concerns during treatment.

When using this medication, some common side effects that you might experience include burning, itching, dry or red skin at the application site, as well as digestive issues such as nausea, upset stomach, or changes in taste. These effects are usually mild, but if they persist or worsen, it's advisable to consult your healthcare provider for guidance.

In addition to the common side effects, some users report headaches, sleepiness, dizziness, numbness, or a pins-and-needles sensation. While these are generally not severe, monitoring their presence and communicating with your healthcare provider can be beneficial.

There are also serious side effects to be aware of, although they are rare. Immediate medical attention is necessary if you experience signs of liver problems, such as persistent nausea, fatigue, or yellowing of the skin and eyes. Kidney issues may manifest as irregular heartbeat or reduced urine output. Heart-related symptoms, including chest pain or shortness of breath, could indicate a heart attack or heart failure. Additionally, stroke symptoms like weakness on one side of the body or slurred speech require urgent care. Be alert for signs of digestive tract bleeding, such as black stools or severe stomach pain. Serious allergic reactions, characterized by hives, swelling, or difficulty breathing, and severe skin reactions like painful rashes or blisters, also warrant immediate medical help.

Overall, while many people using this medication do not experience severe side effects, being informed and vigilant about them is important for your safety and wellbeing.

This medication can interact with several other drugs. These include aliskiren, ACE inhibitors like captopril and lisinopril, angiotensin II receptor blockers such as losartan and valsartan, and cidofovir. Additionally, corticosteroids (e.g., prednisone), lithium, methotrexate, and diuretics like furosemide may also interact with this drug.

There is an increased risk of bleeding if this medication is taken with other drugs that cause bleeding, such as anti-platelet medications like clopidogrel and blood thinners such as dabigatran, enoxaparin, or warfarin.

Be vigilant about reading labels on all prescription and over-the-counter medicines, as many contain pain relievers or fever reducers, such as aspirin and NSAIDs like celecoxib, ibuprofen, or ketorolac. These are similar to diclofenac and may heighten the likelihood of side effects if used together. If your healthcare provider has advised you to take low-dose aspirin to reduce the risk of heart attack or stroke (typically 81-162 milligrams daily), continue doing so unless otherwise directed by your doctor. Consult your doctor or pharmacist for further guidance.