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This document outlines crucial safety information and warnings for the medication Urelle. It is vital to understand these risks and precautions to ensure safe use. If you have any questions or concerns, please discuss them with your healthcare provider.

• Risk of Medication Interaction: If you are taking any drugs that increase serotonin levels, such as fluoxetine (Prozac), it is important to inform your healthcare provider before using Urelle. Urelle contains methylene blue, which can interfere with serotonin breakdown. Concurrent use with serotonin-increasing medications may lead to a severe condition known as serotonin syndrome. Symptoms to watch for include confusion, muscle twitching, shaking, and diarrhea.

• Allergic Reactions: There is a possibility of allergic reactions to Urelle, especially if you have previously reacted to belladonna alkaloids like atropine and scopolamine (Transderm Scop), or salicylates such as aspirin. It is crucial to inform your provider about any past allergies to these substances to avoid adverse reactions.

Please note that there are no listed contraindications for Urelle at this time. Always consult your healthcare provider for personalized advice and guidance regarding medication use.

When taking this medication, some individuals might experience common side effects such as nausea, vomiting, dry mouth, dizziness, drowsiness, blurred vision, or constipation. These effects are generally mild, and strategies like sucking on sugarless candy or staying hydrated can help manage dry mouth. Uniquely, this medication may cause urine and stools to appear blue-green, a harmless effect that will subside once you stop the medication.

If you encounter more serious side effects, it's important to seek medical advice. These include hot, dry, or flushed skin, reduced sweating, eye pain, or difficulty urinating, as well as symptoms of potential kidney problems like changes in urination patterns. In rare cases, the drug can lead to a hypertensive crisis, which is critical and needs immediate attention. Symptoms might include severe headache, irregular heartbeat, chest pain, neck stiffness, pronounced nausea, or vision changes.

Furthermore, very serious allergic reactions, although rare, demand prompt medical intervention. Watch for signs such as rash, severe dizziness, swelling in the face or throat, or trouble breathing. Always consult with a healthcare provider about any new or worsening symptoms to ensure your safety while using this medication.

This medication can interact with various products and drugs. It is important to be cautious if you're using any of the following: apraclonidine, atomoxetine, bupropion, carbamazepine, dichlorphenamide, methotrexate, mifepristone, potassium capsules or tablets, pramlintide, tetrabenazine, certain Parkinson's disease medications (like entacapone, levodopa, tolcapone), certain high blood pressure medications (such as guanethidine, methyldopa), sulfonamide drugs (including antibiotics like sulfamethoxazole), and sympathomimetics (such as amphetamine, ephedrine). Additionally, products that reduce the acid level in urine, such as antacids, sodium bicarbonate, potassium/sodium citrate, and acetazolamide, may also interact.

This medication may heighten the risk of bleeding if taken with other drugs that also increase bleeding risk, such as anti-platelet drugs like clopidogrel and blood thinners like dabigatran, enoxaparin, or warfarin.

It is crucial to avoid combining this medication with other MAO inhibitors, as this can lead to a serious, potentially fatal drug interaction. Avoid taking MAO inhibitors like isocarboxazid, linezolid, metaxalone, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, and tranylcypromine during treatment, and for two weeks before and after using this medication. Consult your doctor about the appropriate timing for starting or stopping these medications.

If you are using products that might increase the risk of extremely high blood pressure (hypertensive crisis) when combined with this medication, such as herbal products like ephedra/ma huang, nasal decongestants like phenylephrine or pseudoephedrine, stimulants, and diet aids, you should not use this medication alongside them. Discuss this with your healthcare provider.

For those also taking azole antifungal drugs, such as itraconazole or ketoconazole, it is advised to take this medication at least two hours after the antifungal.

Examine all prescription and over-the-counter medicine labels carefully, as many may contain pain relievers or fever reducers similar to salicylate, such as aspirin and NSAIDs like ibuprofen, ketorolac, or naproxen, which can increase side effects if used together. If you have been advised by your doctor to take low-dose aspirin for heart attack or stroke prevention, continue as directed unless advised otherwise.

Inform your healthcare provider if you are using other products that cause drowsiness, including alcohol, marijuana, antihistamines, sleep or anxiety medications, muscle relaxants, and opioid pain relievers. Check all medicine labels, including those for allergies or cough-and-cold products, for ingredients that might cause drowsiness.

Finally, this medication may affect certain lab tests, possibly causing incorrect results. Ensure all your healthcare providers and lab personnel know you are taking this drug.